Sodium meta-Periodate (NaIO4) is a useful reagent for the oxidation of carbohydrates to aldehydes.Sodium meta-Periodate converts hydroxyls (-OH) to aldehydes that then react with hydrizide groups.Sodium m-Periodate reacts most efficiently with cis-diols (as found in Sialic Acid) at a concentration of 1mM, but increasing concentrations (>10mM) should ensure oxidation of many sugar residues.Carbohydrate moites on glycoproteins can be conveniently oxidized to aldehydes in a 10mM periodate solution for 30 minutes and then desatled.The resulting aldehydes can be conjugated to hydrizide groups of PDPH crosslinker or Biotin-Hydrizide for protein crosslinking or biotinylation of your glycoprotein, respectively.
Molecular Weight: 213.89CAS Number: 7790-28-5Alternative Name: Sodium Periodate; Periodic Acid (HIO4), Sodium Salt; NaIO4ProteoChem是一家生物技术和化学试剂制造公司，专门从事蛋白质生物化学和有机合成。ProteoChem生产用于NMR，质谱，蛋白质交联剂和用于蛋白质检测和蛋白质修饰的新型蛋白质组学试剂的分析标准品，这些试剂用于质谱，药物开发，诊断和蛋白质生物学中。
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