Succinimidyl6-(3-[2-pyridyldithio]-propionamido)hexanoate(LC-SPDP)isacleavable,waterinsoluble,aminoandthiol(sulfhydryl)reactiveheterobifunctionalcrosslinkingreagent.The"longchain"LC-SPDPcrosslinkingreagenthasa15.7angstromspacerarm,comparedtotheshorter6.8angstromspacerarmversionofSPDPcrosslinker.Often,duetosterichindrances,itisdesirabletoempiricallytestwhichofthetwoversionswillworkbestinyourspecificapplication.
LC-SPDPcrosslinkingreagent"sreactivemoitesconsistofanN-hydroxysuccinimide(NHS)esterthatreactswithprimaryamines,asfoundinlysinesidechains.WhileontheotherendoftheLC-SPDPcrosslinkingreagentpyridinyldisulfidereactswithsulhydrylstoyieldarevers
IBLedisulfidebond.
MolecularWeight:425.5
SpacerLength:15.7Å
SpecialbulkpricingisavailableonbulkquantitiesofLC-SPDPcrosslinkingreagentforyourlargevolumemanufacturingapplication.