ProteoChem"sultrapure,zero-lengthcrosslinker1-Ethyl-3-(3-dimethylaminopropyl)carbodiimidehydrochloride(EDC-HClorEDAC-HCl)isusedtoconjugatecarboxylfunctionalgroupstoprimaryaminesasfoundinpeptidesandproteins.Itisidealforcovalentlybindingproteinsorpeptidestocarboxylcontainingbeads,resins,orothernanoparticals.EDC-HCliswatersoluble,thusthereactioncantakeplaceatphysiologicalconditions;althoughthebestresultstakeplaceatpHof5.5orlessbufferedinMES.Sulfo-NHSorNHSisusedasacatalystforEDC-HClcouplingandgreatlyincreasestheefficiencyofthereaction.