Sulfo-LC-SPDPproteincrosslinkingreagent,Sulfosuccinimidyl6-(3"-[2-pyridyldithio]-propionamido)hexanoate,isoneofthreeSPDPvariantsproducedby
ProteoChem(LC-SPDPistheother).Sulfo-LC-SPDPisacleavable,watersoluble,aminoandthiol(sulfhydryl)reactiveheterobifunctionalproteincrosslinker.The"longchain"Sulfo-LC-SPDPcrosslinkingreagenthasa15.7angstromspacerarm,andisthewatersolubleanalogofLC-SPDPcrosslinker.
Sulfo-LC-SPDPcrosslinker"sreactivegroupsincludeN-hydroxysulfosuccinimide(Sulfo-NHS)esterthatreactswithprimaryamines,asfoundinlysinesidechains;whileontheotherendoftheSulfo-LC-SPDPcrosslinkingmoleculepyridinyldisulfidereactswithsulhydrylstoyieldarevers
IBLedisulfidebond.ThedisulfidebondcanbereducedwithTCEP-HClorDTTtoreversethecrosslinkedproteins.
MolecularWeight:527.57
SpacerLength:15.7Å
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SpecialbulkpricingisavailableonbulkquantitiesofSulfo-LC-SPDPcrosslinkerforyourlargevolumemanufacturingapplication.