ProteoChem"s1-Ethyl-3-(3-dimethylaminopropyl)carbodiimidehydrochloride(EDC-HClorEDAC-HCl;EDCorEDAC)isanultrapure,zero-lengthcrosslinkerthatisusedtoconjugatecarboxylfunctionalgroupstoprimaryaminesasfoundinpeptidesandproteins.Itisidealforcovalentlybindingproteinsorpeptidestocarboxylcontainingbeads,resins,orothernanoparticals.EDC-HCliswatersoluble,thusEDCcouplinginwatercantakeplaceatphysiologicalconditions;althoughthebestresultstakeplaceatpHof5.5orlessbufferedinMES.Sulfo-NHSorNHSisusedasacatalystforEDC-HClcouplingandgreatlyincreasestheefficiencyofthereaction.