ProteoChem"s1-Ethyl-3-(3-dimethylaminopropyl)carbodiimidehydrochloride(EDCorEDAC;EDC-HClorEDAC-HCl;EDCI)isanultrapure,zero-lengthcrosslinkerthatisusedtoconjugatecarboxylfunctionalgroupstoprimaryaminesasfoundinpeptidesandproteins.Itisidealforcovalentlybindingproteinsorpeptidestocarboxylcontainingbeads,resins,orothernanoparticals.EDC-HCliswatersoluble,thusthereactioncantakeplaceatphysiologicalconditions;althoughthebestresultstakeplaceatpHof5.5orlessbufferedinMES.Sulfo-NHSorNHSisusedasacatalystforEDC-HClcouplingandgreatlyincreasestheefficiencyofthereaction.