DSP-d8deuteratedcrosslinkingreagent,Dithiobis(succinimidyl2,2,3,3,6,6,7,7-propionate-d8),isacellmembranepermeable,homobifunctional,proteincrosslinkercontainingeightdeuteriumatomstoprovideaneightDaltonshiftbymassspeccomparedtothenon-dueteratedDSP(DSP-d
0).DSP-d8deuteratedcrosslinkingthakesplaceviaamine-reactiveNHSestersatbothendsofacleavable,8-atom(12.0angstrom)spacerarm.Thedeuteratedcrosslinkingspacerarmcontainsareduc
IBLedisulfidebond(SS-bond)whichmakesitagoodchoicefornumerousapplicationswherereversiblecrosslinkingisdesired.
UsetheheavyDSP-d8deuteratedproteincrosslinkerincombinationwiththelight,non-deuteratedanalog(DSP-d
0)formassspecstudies.
DSP-d8deuteratedcrosslinkermustbedissolvedinanorganicsolvent,suchasDMSOorDMF,andthenmaybeaddedtoanaqueouscrosslinkingreaction.SinceDSP-d8crosslinkingreagentiscellmembranepermeableitmaybeusedtocrosslinkintracellularproteins.
MolecularWeight:412.46
SpacerLength:12.0Å
Alternativenames:DSP-d
8;D8-DSP;Dithiobis(succinimidylpropionate-d8);DTSP-d8
SpecialbulkpricingisavailableforbulkquantitiesofDSP-d8deuteratedcrosslinkingreagentforyourlargevolumemanufacturingapplication.